Purified recombinant human TAB1 (N-terminus) protein fragments expressed in E.coli.

TAB1 Monoclonal Antibody detects endogenous levels of TAB1 protein.

TAB1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

TAB1 ;
MAP3K7IP1 ;
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 ;
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 ;
TGF-beta-activated kinase 1-binding protein 1 ;
TAK1-binding protein 1

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr

Function:May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with MAP3K7, XIAP and BIRC7.,tissue specificity:Ubiquitous.,

nucleoplasm,cytoplasm,cytosol,endosome membrane,protein complex,

Ubiquitous.

>>MAPK signaling pathway ;
>>NF-kappa B signaling pathway ;
>>Osteoclast differentiation ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>TNF signaling pathway ;
>>Alcoholic liver disease ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Yersinia infection ;
>>Leishmaniasis ;
>>Toxoplasmosis ;
>>Hepatitis B ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Lipid and atherosclerosis