Synthesized acetyl-peptide derived from human 14-3-3-pan around the acetylation site of K51.

This antibody detects endogenous Acetyl levels of 14-3-3 beta/alpha site of K51.This antibody also recognizes 14-3-3 gamma/theta/zeta/delta when phosphorylated at the corresponding sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AYkNV

YWHAB/YWHAG/YWHAQ/YWHAZ/SFN

14-3-3 protein beta/alpha/14-3-3 protein gamma/14-3-3 protein theta/14-3-3 protein zeta/delta/14-3-3 protein sigma

YWHAB ;
14-3-3 protein beta/alpha ;
Protein 1054 ;
Protein kinase C inhibitor protein 1 ;
KCIP-1 ;
YWHAG ;
14-3-3 protein gamma ;
Protein kinase C inhibitor protein 1 ;
KCIP-1 ;
YWHAQ ;
14-3-3 protein theta ;
14-3-3 protein T-cell ;
14-3-3 protein tau ;
Protein HS1 ;
YWHAZ ;
14-3-3 protein zeta/delta ;
Protein kinase C inhibitor protein 1 ;
KCIP-1 ;
SFN ;
HME1 ;
14-3-3 protein sigma ;
Epithelial cell marker protein 1 ;
Stratifin

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008],

Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.,PTM:Isoform Short contains a N-acetylmethionine at position 1.,PTM:The alpha, brain-specific form differs from the beta form in being phosphorylated.,similarity:Belongs to the 14-3-3 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues.,

Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Vacuole membrane . (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. .

Brain,Colon carcinoma,Kerat

>>Cell cycle ;
>>Oocyte meiosis ;
>>PI3K-Akt signaling pathway ;
>>Hippo signaling pathway ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Viral carcinogenesis