Purified recombinant Human EGFR

This recombinant monoclonal antibody can detects endogenous levels of EGFR protein.

EGFR

Epidermal growth factor receptor

EGFR ;
ERBB ;
ERBB1 ;
HER1 ;
Epidermal growth factor receptor ;
Proto-oncogene c-ErbB-1 ;
Receptor tyrosine-protein kinase erbB-1 ;
EGFR nanobody ;

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in EGFR are associated with lung cancer [MIM:211980].,Function:Isoform 2/truncated isoform may act as an antagonist.,Function:Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin.,miscellaneous:Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.,online information:EGFR entry,PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.,PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. Binds MUC1.,tissue specificity:Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.,

Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.

Produced by skeletal muscle.

>>EGFR tyrosine kinase inhibitor resistance ;
>>Antifolate resistance ;
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>HIF-1 signaling pathway ;
>>FoxO signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Cellular senescence ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>C-type lectin receptor signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Hematopoietic cell lineage ;
>>IL-17 signaling pathway ;
>>Th17 cell differentiation ;
>>TNF signaling pathway ;
>>Intestinal immune network for IgA production ;
>>Insulin resistance ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Pertussis ;
>>Legionellosis ;
>>Yersinia infection ;
>>Chagas disease ;
>>African trypanosomiasis ;
>>Malaria ;
>>Amoebiasis ;
>>Tuberculosis ;
>>Hepatitis B ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Inflammatory bowel disease ;
>>Rheumatoid arthritis ;
>>Graft-versus-host disease ;
>>Hypertrophic cardiomyopathy ;
>>Lipid and atherosclerosis