HNRNPC

Heterogeneous nuclear ribonucleoproteins C1/C2 ;
hnRNP C1/C2 ;

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) . These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus , some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq , Jul 2008] ,

Function:Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. ,PTM:Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. ,PTM:Sumoylated. Sumoylation reduces affinity for mRNA. ,similarity:Belongs to the RRM HNRPC family. RALY subfamily. ,similarity:Contains 1 RRM (RNA recognition motif) domain. ,subcellular location:Component of ribonucleosomes. ,subunit:Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex , at least composed of AQR , ASCC3L1 , C19orf29 , CDC40 , CDC5L , CRNKL1 , DDX23 , DDX41 , DDX48 , DDX5 , DGCR14 , DHX35 , DHX38 , DHX8 , EFTUD2 , FRG1 , GPATC1 , HNRNPA1 , HNRNPA2B1 , HNRPA3 , HNRNPC , HNRPF , HNRPH1 , HNRPK , HNRPM , HNRNPR , HNRNPU , KIAA1160 , KIAA1604 , LSM2 , LSM3 , MAGOH , MORG1 , PABPC1 , PLRG1 , PNN , PPIE , PPIL1 , PPIL3 , PPWD1 , PRPF19 , PRPF4B , PRPF6 , PRPF8 , RALY , RBM22 , RBM8A , RBMX , SART1 , SF3A1 , SF3A2 , SF3A3 , SF3B1 , SF3B2 , SF3B3 , SFRS1 , SKIV2L2 , SNRPA1 , SNRPB , SNRPB2 , SNRPD1 , SNRPD2 , SNRPD3 , SNRPE , SNRPF , SNRPG , SNW1 , SRRM1 , SRRM2 , SYF2 , SYNCRIP , TFIP11 , THOC4 , U2AF1 , WDR57 , XAB2 and ZCCHC8. ,

Nucleus. Component of ribonucleosomes.