STAT6

Signal transducer and activator of transcription 6 ;
IL-4 Stat ;

function:Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. ,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus in response to phosphorylation. ,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity) . Interacts with NCOA1 via its C-terminal LXXLL motif. ,

regulation of DNA recombination , regulation of immunoglobulin production , negative regulation of immune system process , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of immune effector process , regulation of production of molecular mediator of immune response , regulation of leukocyte mediated immunity , regulation of lymphocyte mediated immunity , regulation of B cell mediated immunity , regulation of adaptive immune response , negative regulation of adaptive immune response ,regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , regulation of T-helper 2 type immune response , negative regulation of T-helper 2 type immune response , regulation of immunoglobulin mediated immune response , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , positive regulation of biosynthetic process , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , cytokine-mediated signaling pathway , positive regulation of cellular biosynthetic process , response to cytokine stimulus , regulation of cell proliferation , regulation of isotype switching , regulation of transcription , positive regulation of isotype switching , positive regulation of transcription , DNA-dependent , positive regulation of DNA recombination , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter ,regulation of isotype switching to IgE isotypes , positive regulation of isotype switching to IgE isotypes , negative regulation of response to stimulus , negative regulation of immune response , regulation of B cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of B cell activation , regulation of DNA metabolic process , positive regulation of DNA metabolic process , positive regulation of nitrogen compound metabolic process , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of RNA metabolic process , positive regulation of RNA metabolic process ,

Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.