PDGFRA PDGFR2 RHEPDGFRA

Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)

Platelet-derived growth factor receptor alpha ;
PDGF-R-alpha ;
PDGFR-alpha ;
Alpha platelet-derived growth factor receptor ;
Alpha-type platelet-derived growth factor receptor ;
CD140 antigen-like family member A ;
CD140a antigen ;
Platelet-derived growth factor alpha receptor ;
Platelet-derived growth factor receptor 2 ;
PDGFR-2 ;
CD antigen CD140a ;

platelet derived growth factor receptor alpha (PDGFRA) Homo sapiens This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer , composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development , wound healing , and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome , somatic and familial gastrointestinal stromal tumors , and a variety of other cancers. [provided by RefSeq , Mar 2012] ,

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA , PDGFB and PDGFC and plays an essential role in the regulation of embryonic development , cell proliferation , survival and chemotaxis. Depending on the context , promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract , and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation , secretion of agonists from platelet granules , and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA , homodimeric PDGFB , heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1 , PLCG1 , and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1 ,4 ,5-trisphosphate , mobilization of cytosolic Ca (2+) and the activation of protein kinase C. Phosphorylates PIK3R1 , the regulatory subunit of phosphatidylinositol 3-kinase , and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1 , STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors , and by rapid internalization of the activated receptor.

Cell membrane ; Single-pass type I membrane protein . Cell projection , cilium . Golgi apparatus .

>>EGFR tyrosine kinase inhibitor resistance ;
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>Gap junction ;
>>JAK-STAT signaling pathway ;
>>Regulation of actin cytoskeleton ;
>>Human cytomegalovirus infection ;
>>Pathways in cancer ;
>>MicroRNAs in cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Central carbon metabolism in cancer ;
>>Choline metabolism in cancer