ICAM1

Intercellular adhesion molecule 1 ;
ICAM-1 ;
Major group rhinovirus receptor ;
CD antigen CD54 ;

function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . During leukocyte trans-endothelial migration , ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. ,online information:ICAM-1 ,online information:Icosahedral capsid structure ,online information:Intercellular adhesion molecule entry ,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria. ,PTM:Monoubiquitinated , which is promoted by MARCH9 and leads to endocytosis. ,similarity:Belongs to the immunoglobulin superfamily. ICAM family. ,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Homodimer (Probable) . Interacts with human herpesvirus 8 MIR2 protein (Probable) . Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. ,

cell activation , regulation of leukocyte mediated cytotoxicity , adaptive immune response , immune effector process , cell activation during immune response , lymphocyte activation during immune response , T cell activation during immune response , T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ,leukocyte activation during immune response , leukocyte mediated immunity , lymphocyte mediated immunity , T cell mediated immunity , T cell antigen processing and presentation , adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , positive regulation of immune system process , regulation of leukocyte migration , positive regulation of leukocyte migration , regulation of cellular extravasation , positive regulation of cellular extravasation , regulation of immune effector process , cell motion , immune response , cell adhesion , heterophilic cell adhesion , leukocyte adhesion , positive regulation of biosynthetic process ,viral reproduction , cell-cell adhesion , cell migration , viral infectious cycle , initiation of viral infection , virion attachment to host cell surface receptor , antigen processing and presentation , membrane docking , viral reproductive process ,biological adhesion , membrane to membrane docking , regulation of cell adhesion , entry into host cell , regulation of cell migration , positive regulation of cell migration , positive regulation of cellular biosynthetic process , regulation of cell killing , cell adhesion mediated by integrin , regulation of locomotion , positive regulation of locomotion , T cell activation ,positive regulation of DNA binding , positive regulation of molecular function , entry into host , leukocyte activation ,regulation of nitric oxide biosynthetic process , positive regulation of nitric oxide biosynthetic process , regulation of transcription , lymphocyte activation , entry of virus into host cell , virion attachment , binding of host cell surface receptor , cell motility , leukocyte migration , regulation of transcription factor activity , positive regulation of transcription factor activity , positive regulation of NF-kappaB transcription factor activity , regulation of binding , positive regulation of binding , regulation of DNA binding , positive regulation of nitrogen compound metabolic process , regulation of cell motion , positive regulation of cell motion , localization of cell , interaction with symbiont , entry into cell of other organism during symbiotic interaction , adhesion to other organism during symbiotic interaction , entry into other organism during symbiotic interaction , adhesion to symbiont , movement in host environment , movement in environment of other organism during symbiotic interaction ,

Membrane; Single-pass type I membrane protein.