FYN

Tyrosine-protein kinase Fyn ;
Proto-oncogene Syn ;
Proto-oncogene c-Fyn ;
Src-like kinase ;
SLK ;
p59-Fyn ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,cofactor:Manganese. ,enzyme regulation:Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site. ,function:Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels , with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth , axon guidance , and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 1 SH3 domain. ,subcellular location:Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes. ,subunit:Associates through its SH3 domain , to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB) . Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity) . Interacts with PAG1. Interacts (via SH3 domain) with PRMT8. Interacts with SH2D1A and SLAMF1. Interacts (via SH3 domain) with HEV ORF3 protein. ,tissue specificity:Isoform 1 is highly expressed in the brain , isoform 2 is expressed in cells of hemopoietic lineages , especially T lymphocytes. ,

neuron migration , cell activation , activation of immune response , immune response-activating cell surface receptor signaling pathway , positive regulation of immune system process , immune response-activating signal transduction ,immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway ,protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , ion transport ,cation transport , calcium ion transport , cell motion , cell surface receptor linked signal transduction , intracellular signaling cascade , protein kinase cascade , sensory perception , behavior , learning or memory , learning , feeding behavior , cell proliferation , regulation of cell shape , detection of external stimulus , detection of abiotic stimulus ,response to mechanical stimulus , response to abiotic stimulus , response to organic substance , di- , tri-valent inorganic cation transport , phosphorylation , cell migration , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification ,sensory perception of pain , regulation of cell morphogenesis , metal ion transport , forebrain development ,mononuclear cell proliferation , T cell proliferation , T cell activation , leukocyte activation , response to ethanol ,lymphocyte activation , lymphocyte proliferation , protein amino acid autophosphorylation , positive regulation of response to stimulus , cell motility , positive regulation of immune response , activated T cell proliferation , antigen receptor-mediated signaling pathway , T cell receptor signaling pathway , neurological system process , cognition ,detection of stimulus involved in sensory perception , sensory perception of mechanical stimulus , detection of mechanical stimulus involved in sensory perception of pain , detection of mechanical stimulus involved in sensory perception , detection of mechanical stimulus , detection of stimulus , localization of cell , leukocyte proliferation ,

Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.