STAT5A/STAT5B

function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription. ,online information:STAT5 entry ,PTM:Tyrosine phosphorylated in response to IL-2 , IL-3 , IL-7 , IL-15 , GM-CSF , growth hormone , prolactin , erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus in response to phosphorylation. ,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity) . Interacts with NCOA1 and SOCS7. ,

allantoin metabolic process , luteinization , cell activation , leukocyte homeostasis , natural killer cell differentiation ,regulation of cytokine production , regulation of leukocyte mediated cytotoxicity , positive regulation of leukocyte mediated cytotoxicity , lymphocyte homeostasis , immune system development , leukocyte differentiation , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation ,regulation of immune effector process , positive regulation of immune effector process , regulation of leukocyte mediated immunity , positive regulation of leukocyte mediated immunity , regulation of lymphocyte mediated immunity ,positive regulation of lymphocyte mediated immunity , regulation of natural killer cell mediated immunity , positive regulation of natural killer cell mediated immunity , regulation of myeloid leukocyte differentiation , positive regulation of myeloid leukocyte differentiation , reproductive developmental process , citrate metabolic process , 2-oxoglutarate metabolic process , succinate metabolic process , oxaloacetate metabolic process , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , protein amino acid phosphorylation , isoleucine metabolic process , valine metabolic process , cellular amino acid derivative metabolic process , phosphagen metabolic process , creatine metabolic process , fatty acid metabolic process , sulfur metabolic process , phosphorus metabolic process , phosphate metabolic process , anti-apoptosis , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , JAK-STAT cascade , regulation of mitotic cell cycle , sex differentiation , female pregnancy , lactation , positive regulation of cell proliferation , gonad development , female gonad development , branched chain family amino acid metabolic process , response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , lipid localization , regulation of cell death , phosphorylation , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , regulation of lipid metabolic process , regulation of steroid metabolic process , cytokine-mediated signaling pathway , taurine metabolic process , lipid storage , ovulation cycle process , hemopoiesis , lymphocyte differentiation , natural killer cell activation , regulation of cell adhesion , T cell differentiation , regulation of epithelial cell differentiation , mammary gland development , positive regulation of cellular biosynthetic process , regulation of cell killing , positive regulation of cell killing , positive regulation of defense response ,regulation of response to external stimulus , positive regulation of response to external stimulus , multicellular organism reproduction , regulation of interleukin-2 production , regulation of natural killer cell activation , positive regulation of natural killer cell activation , regulation of natural killer cell differentiation , positive regulation of natural killer cell differentiation , regulation of homeostatic process , cellular response to hormone stimulus , regulation of mononuclear cell proliferation , positive regulation of mononuclear cell proliferation , regulation of mast cell apoptosis ,negative regulation of mast cell apoptosis , regulation of myeloid cell apoptosis , negative regulation of myeloid cell apoptosis , T cell differentiation in the thymus , regulation of growth , regulation of multicellular organism growth ,positive regulation of multicellular organism growth , regulation of cytokine biosynthetic process , positive regulation of T cell proliferation , positive regulation of activated T cell proliferation , positive regulation of cytokine biosynthetic process , T cell activation , regulation of cell proliferation , regulation of T cell proliferation , regulation of natural killer cell mediated cytotoxicity , homeostatic process , ovulation cycle , regulation of apoptosis , T cell homeostasis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , response to peptide hormone stimulus , cellular amide metabolic process , dicarboxylic acid metabolic process , regulation of interleukin-2 biosynthetic process , positive regulation of interleukin-2 biosynthetic process , regulation of innate immune response , positive regulation of innate immune response , development of secondary sexual characteristics ,development of primary sexual characteristics , leukocyte activation , regulation of transcription , regulation of B cell differentiation , positive regulation of B cell differentiation , regulation of T cell differentiation , positive regulation of T cell differentiation , regulation of gamma-delta T cell differentiation , positive regulation of gamma-delta T cell differentiation , negative regulation of cell differentiation , positive regulation of cell differentiation , regulation of lymphocyte differentiation , positive regulation of lymphocyte differentiation , regulation of myeloid cell differentiation ,negative regulation of myeloid cell differentiation , positive regulation of myeloid cell differentiation , regulation of erythrocyte differentiation , negative regulation of erythrocyte differentiation , positive regulation of cell cycle ,regulation of survival gene product expression , positive regulation of survival gene product expression , positive regulation of transcription , DNA-dependent , positive regulation of growth , positive regulation of mitotic cell cycle ,positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , positive regulation of natural killer cell mediated cytotoxicity , regulation of activated T cell proliferation , creatinine metabolic process , development of secondary female sexual characteristics , development of secondary male sexual characteristics , development of primary female sexual characteristics , regulation of gamma-delta T cell activation , positive regulation of gamma-delta T cell activation , lymphocyte activation , female sex differentiation , male sex differentiation , rhythmic process ,hemopoietic or lymphoid organ development , mucosal-associated lymphoid tissue development , Peyer's patch development , positive regulation of response to stimulus , reproductive structure development , reproductive process in a multicellular organism , gland development , homeostasis of number of cells , regulation of lymphocyte proliferation ,positive regulation of lymphocyte proliferation , regulation of inflammatory response , positive regulation of inflammatory response , positive regulation of immune response , regulation of T cell activation , regulation of B cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of T cell activation ,positive regulation of B cell activation , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process , positive regulation of multicellular organismal process , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of cell cycle , regulation of mast cell differentiation , positive regulation of mast cell differentiation , growth hormone receptor signaling pathway , JAK-STAT cascade involved in growth hormone signaling pathway , response to growth hormone stimulus , negative regulation of cell death , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation ,

Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.