Catalog: KA1222C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Collected
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Main Information
Reactivity
Human, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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STAT2 Rabbit pAb
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Primary Antibodies
STAT2 (Phospho Tyr690) Rabbit pAb
YP0612
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ELISA Kits
Total STAT2 Cell-Based Colorimetric ELISA Kit
KA4291C
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ELISA Kits
STAT2 (Phospho Tyr690) Cell-Based Colorimetric ELISA Kit
KA1222C
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Antigen&Target Information
Gene Name:
STAT2
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Other Name:
Signal transducer and activator of transcription 2 ;
p113 ;
p113 ;
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Background:
function:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors , Jak kinases (TYK2 and JAK1) are activated , leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize , associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor , that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes , which drive the cell in an antiviral state. ,PTM:Tyrosine phosphorylated in response to IFN-alpha. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta. ,subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein. ,
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Function:
transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter ,intracellular signaling cascade , protein kinase cascade , JAK-STAT cascade , response to virus , regulation of transcription , regulation of RNA metabolic process ,
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Cellular Localization:
Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Chemokine signaling pathway
Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
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Catalog: KA1222C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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