CASP6

Caspase-6 ;
CASP-6 ;
Apoptotic protease Mch-2 ;
[Cleaved into: Caspase-6 subunit p18 ;
Caspase-6 subunit p11]

catalytic activity:Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-. ,enzyme regulation:Activation is suppressed by phosphorylation at Ser-257. ,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly (ADP-ribose) polymerase in vitro , as well as lamins. Overexpression promotes programmed cell death. ,PTM:Cleavages by caspase-3 , caspase-8 or -10 generate the two active subunits. ,similarity:Belongs to the peptidase C14A family. ,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers , each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. ,

response to reactive oxygen species , eye development , lens development in camera-type eye , acute inflammatory response to non-antigenic stimulus , acute inflammatory response , proteolysis , apoptosis , induction of apoptosis ,defense response , inflammatory response , response to oxidative stress , sensory organ development , cell death ,response to temperature stimulus , response to radiation , response to heat , response to wounding , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , response to carbohydrate stimulus , response to hexose stimulus , response to glucose stimulus , response to organic substance , response to inorganic substance , response to metal ion , response to iron ion , response to ionizing radiation , response to organic nitrogen , response to gamma radiation , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , response to estradiol stimulus , response to testosterone stimulus ,response to cytokine stimulus , response to monosaccharide stimulus , response to hydrogen peroxide , regulation of apoptosis , camera-type eye development , positive regulation of apoptosis , regulation of programmed cell death ,positive regulation of programmed cell death , regulation of neuron apoptosis , positive regulation of neuron apoptosis ,response to estrogen stimulus , regulation of retinal cell programmed cell death , positive regulation of retinal cell programmed cell death , response to steroid hormone stimulus , positive regulation of developmental process ,regulation of cell development ,

Cytoplasm . Nucleus .