Reconstitute in sterile water for a stock solution
Formulation
Supplied as solution form in 150 mM NaCl, 50 mM Tris-HCl, pH 7.5./ Lyophilized from 150 mM NaCl, 50 mM Tris-HCl, pH 7.5.
Source
Mammalian cells
Purity
>90% as determined by SDS-PAGE
Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Antigen&Target Information
Sequence:
A DNA sequence encoding the human CTLA4(Met1~Asp161) was fused with the C-terminal His Tag
Cell membrane ; Single-pass type I membrane protein . Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization.
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Tissue Expression:
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.