NTRK2

BDNF/NT-3 growth factors receptor ;
GP145-TrkB ;
Trk-B ;
Neurotrophic tyrosine kinase receptor type 2 ;
TrkB tyrosine kinase ;
Tropomyosin-related kinase B ;

alternative products:Additional isoforms seem to exist ,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,function:Receptor for brain-derived neurotrophic factor (BDNF) , neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF) . Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1 , PI-3 kinase , and PLC-gamma-1. ,PTM:Ligand-mediated auto-phosphorylation. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains. ,similarity:Contains 2 LRR (leucine-rich) repeats. ,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220. ,tissue specificity:Isoform TrkB is widely expressed , mainly in the nervous tissue. In the CNS , expression is observed in the cerebral cortex , hippocampus , thalamus , choroid plexus , granular layer of the cerebellum , brain stem , and spinal cord. In the peripheral nervous system , it is expressed in many cranial ganglia , the ophtalmic nerve , the vestibular system , multiple facial structures , the submaxillary glands , and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues , mainly in brain , pancreas , kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain. ,

blood vessel development , vasculogenesis , eye development , eye photoreceptor cell differentiation , vasculature development , generation of a signal involved in cell-cell signaling , regulation of nucleotide metabolic process , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , activation of adenylate cyclase activity , cell-cell signaling , sensory organ development ,behavior , feeding behavior , positive regulation of cell communication , regulation of neuron projection development ,glutamate secretion , phosphorylation , neuron differentiation , regulation of cyclic nucleotide metabolic process ,regulation of cyclic nucleotide biosynthetic process , regulation of nucleotide biosynthetic process , regulation of cAMP metabolic process , regulation of cAMP biosynthetic process , regulation of cyclase activity , positive regulation of cyclase activity , regulation of cell projection organization , brain-derived neurotrophic factor receptor signaling pathway ,regulation of neurological system process , positive regulation of neurological system process , secretion by cell ,photoreceptor cell development , eye photoreceptor cell development , mechanoreceptor differentiation , positive regulation of catalytic activity , regulation of system process , positive regulation of molecular function , regulation of neuron differentiation , regulation of adenylate cyclase activity , positive regulation of adenylate cyclase activity ,photoreceptor cell differentiation , retinal rod cell development , protein amino acid autophosphorylation , secretion ,regulation of neurotransmitter secretion , blood vessel morphogenesis , eye morphogenesis , neuron development ,regulation of neurogenesis , regulation of dendrite development , regulation of synaptic transmission , positive regulation of synaptic transmission , regulation of secretion , positive regulation of multicellular organismal process ,regulation of lyase activity , positive regulation of lyase activity , regulation of neurotransmitter transport , regulation of nervous system development , regulation of synaptic transmission , glutamatergic , positive regulation of synaptic transmission , glutamatergic , regulation of transmission of nerve impulse , positive regulation of transmission of nerve impulse , regulation of cell development , regulation of cellular localization ,

Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection , axon . Cell projection , dendrite . Cytoplasm , perinuclear region . Cell junction , synapse , postsynaptic density . Internalized to endosomes upon ligand-binding. .