Catalog: KA1170C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
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Collected
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
phosphate
Detailed Information
Storage
2-8°C/6 months,Ship by ice bag
Modification
phosphate
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
NFKBIB
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Other Name:
NF-kappa-B inhibitor beta ;
NF-kappa-BIB ;
I-kappa-B-beta ;
IkB-B ;
IkB-beta ;
IkappaBbeta ;
Thyroid receptor-interacting protein 9 ;
TR-interacting protein 9 ;
TRIP-9 ;
NF-kappa-BIB ;
I-kappa-B-beta ;
IkB-B ;
IkB-beta ;
IkappaBbeta ;
Thyroid receptor-interacting protein 9 ;
TR-interacting protein 9 ;
TRIP-9 ;
show all
Background:
function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However , the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation , explaining its slower degradation. ,PTM:Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. ,similarity:Belongs to the NF-kappa-B inhibitor family. ,similarity:Contains 6 ANK repeats. ,subunit:Interacts with THRB (via ligand-binding domain) . Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. ,tissue specificity:Expressed in all tissues examined. ,
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Function:
transcription , intracellular signaling cascade , protein kinase cascade , I-kappaB kinase/NF-kappaB cascade , cytoplasmic sequestering of NF-kappaB , protein localization , regulation of intracellular transport , negative regulation of intracellular transport , maintenance of protein location in cell , regulation of protein localization , regulation of intracellular protein transport , regulation of protein import into nucleus , negative regulation of protein import into nucleus , regulation of NF-kappaB import into nucleus , negative regulation of NF-kappaB import into nucleus , regulation of transcription factor import into nucleus , negative regulation of transcription factor import into nucleus , cytoplasmic sequestering of transcription factor , maintenance of protein location , regulation of nucleocytoplasmic transport ,negative regulation of nucleocytoplasmic transport , negative regulation of transport , cytoplasmic sequestering of protein , regulation of protein transport , negative regulation of protein transport , maintenance of location ,maintenance of location in cell , regulation of cellular localization , regulation of establishment of protein localization ,
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Cellular Localization:
Cytoplasm . Nucleus .
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Tissue Expression:
show all
Signaling Pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway
Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation
Organismal Systems >> Immune system >> Th17 cell differentiation
Organismal Systems >> Immune system >> B cell receptor signaling pathway
Organismal Systems >> Immune system >> Chemokine signaling pathway
Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
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Catalog: KA1170C
Size
Price
Status
Qty.
96well
$470.00
2 weeks
0
Add to cart
Collected
Collect
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