LIMK1

LIM domain kinase 1 ;
LIMK-1 ;

There are approximately 40 known eukaryotic LIM proteins , so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA , the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog

regulation of cell growth , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cytoskeleton organization , intracellular signaling cascade , small GTPase mediated signal transduction , Ras protein signal transduction , Rho protein signal transduction , regulation of cell size , positive regulation of cell development , regulation of cell morphogenesis involved in differentiation , regulation of neuron projection development , phosphorylation , regulation of cell morphogenesis , actin filament-based process , actin cytoskeleton organization , positive regulation of cell growth , regulation of axon extension , regulation of cell projection organization ,positive regulation of cell projection organization , regulation of cellular component size , regulation of growth , positive regulation of cell differentiation , regulation of neuron differentiation , positive regulation of axon extension , positive regulation of cell size , positive regulation of growth , regulation of developmental growth , positive regulation of developmental growth , regulation of neurogenesis , positive regulation of neurogenesis , regulation of axonogenesis ,positive regulation of axonogenesis , positive regulation of developmental process , positive regulation of cellular component organization , regulation of nervous system development , regulation of cell development ,

Cytoplasm . Nucleus . Cytoplasm , cytoskeleton . Cell projection , lamellipodium . Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA , CDC42BPB and FAM89B/LRAP25-dependent manner. .