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LC3A protein

-YD0061

1 / 0
Main Information
Reactivity

Human

Applications

WB, SDS-PAGE

Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS
Source
E.coli
Purity
SDS-PAGE >90%
Storage
-20°C/6 month,-80°C for long storage
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Antigen&Target Information
Sequence:
Amino acid: 1-77, with his-MBP tag.
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Gene Name:
MAP1LC3A
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Protein Name:
LC3A protein
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Other Name:
Microtubule-associated proteins 1A/1B light chain 3A ;
Autophagy-related protein LC3 A ;
Autophagy-related ubiquitin-like modifier LC3 A ;
MAP1 light chain 3-like protein 1 ;
MAP1A/MAP1B light chain 3 A ;
MAP1A/MAP1B LC3 A ;
Microtubule-associated protein 1 light chain 3 alpha ;
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Database Link:
Organism Gene ID SwissProt
Human 84557; Q9H492;
Mouse Q91VR7;
Background:
function:Probably involved in formation of autophagosomal vacuoles (autophagosomes).,PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:LC3-II binds to the autophagic membranes.,subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.,tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.,
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Function:
autophagic vacuole formation, proteolysis, autophagy, vacuole organization, macromolecule catabolic process, cellular response to starvation, response to extracellular stimulus, macroautophagy, modification-dependent protein catabolic process, protein catabolic process, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to stress, response to starvation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process,proteolysis involved in cellular protein catabolic process,
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Cellular Localization:
Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor . Endomembrane system ; Lipid-anchor . Cytoplasm, cytoskeleton . LC3-II binds to the autophagic membranes. .
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Tissue Expression:
Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
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Catalog: YD0061
Size
Price
Status
Qty.
100μg
$280.00
3 weeks

0

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