ATP1A1

Sodium/potassium-transporting ATPase subunit alpha-1 ;
Na ;
+ ;
/K ;
+ ;
ATPase alpha-1 subunit ;
Sodium pump subunit alpha-1 ;

catalytic activity:ATP + H (2) O + Na (+) (In) + K (+) (Out) = ADP + phosphate + Na (+) (Out) + K (+) (In) . ,function:This is the catalytic component of the active enzyme , which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions , providing the energy for active transport of various nutrients. ,PTM:Phosphorylation on Tyr-10 modulates pumping activity. ,similarity:Belongs to the cation transport ATPase (P-type) family. ,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. ,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,subunit:Composed of three subunits: alpha (catalytic) , beta and gamma. Binds the HLA class II histocompatibility antigen , DR1. ,

regulation of the force of heart contraction , circulatory system process , purine nucleotide metabolic process , purine nucleotide biosynthetic process , ATP biosynthetic process , ion transport , cation transport , potassium ion transport ,sodium ion transport , regulation of muscle contraction , regulation of striated muscle contraction , blood circulation ,regulation of heart contraction , regulation of blood pressure , nucleoside triphosphate metabolic process , nucleoside triphosphate biosynthetic process , purine nucleoside triphosphate metabolic process , purine nucleoside triphosphate biosynthetic process , purine ribonucleotide metabolic process , purine ribonucleotide biosynthetic process , nucleotide biosynthetic process , ribonucleoside triphosphate metabolic process , ribonucleoside triphosphate biosynthetic process , purine ribonucleoside triphosphate metabolic process , purine ribonucleoside triphosphate biosynthetic process , ribonucleotide metabolic process , ribonucleotide biosynthetic process , negative regulation of biosynthetic process , negative regulation of steroid biosynthetic process , monovalent inorganic cation transport , regulation of lipid metabolic process , regulation of steroid metabolic process , metal ion transport , negative regulation of cellular biosynthetic process , regulation of glucocorticoid metabolic process , negative regulation of glucocorticoid metabolic process , regulation of glucocorticoid biosynthetic process , negative regulation of glucocorticoid biosynthetic process ,regulation of hormone metabolic process , negative regulation of hormone metabolic process , negative regulation of hormone biosynthetic process , nucleobase , nucleoside and nucleotide biosynthetic process , nucleobase , nucleoside , nucleotide and nucleic acid biosynthetic process , response to drug , regulation of system process , nitrogen compound biosynthetic process , negative regulation of heart contraction , positive regulation of heart contraction , negative regulation of lipid metabolic process , positive regulation of muscle contraction , negative regulation of steroid metabolic process , positive regulation of striated muscle contraction , ATP metabolic process , regulation of hormone biosynthetic process , regulation of lipid biosynthetic process , regulation of steroid biosynthetic process , negative regulation of lipid biosynthetic process , positive regulation of multicellular organismal process , negative regulation of multicellular organismal process ,

Basolateral cell membrane ; Multi-pass membrane protein . Cell membrane , sarcolemma ; Multi-pass membrane protein . Cell projection , axon . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .