Contact Us

408-747-0189
1-877-594-3616

Quick order

Total LAT Cell-Based Colorimetric ELISA Kit

-KA4159C

Catalog: KA4159C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service
Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
Related Products
Primary Antibodies
LAT Rabbit pAb
YT5665

More→

Primary Antibodies
LAT Rabbit pAb
YT2539

More→

Primary Antibodies
LAT Rabbit pAb
YT2538

More→

Primary Antibodies
LAT Rabbit pAb
YT2537

More→

Primary Antibodies
LAT (Phospho Tyr191) Rabbit pAb
YP0659

More→

Primary Antibodies
LAT (Phospho Tyr200) Rabbit pAb
YP0327

More→

ELISA Kits
Total LAT Cell-Based Colorimetric ELISA Kit
KA4159C

More→

ELISA Kits
LAT (Phospho Tyr191) Cell-Based Colorimetric ELISA Kit
KA1298C

More→

Antigen&Target Information
Gene Name:
LAT
show all
Other Name:
Linker for activation of T-cells family member 1 ;
36 kDa phospho-tyrosine adapter protein ;
pp36 ;
p36-38 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 27040; O43561;
Mouse O54957;
Rat O70601;
Background:
function:Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.,miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC, maybe by inducing the dephosphorylation of LAT.,PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.,PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.,subcellular location:Present in lipid rafts.,subunit:When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A.,tissue specificity:Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).,
show all
Function:
cell activation, immune effector process, cell activation during immune response, myeloid leukocyte activation, myeloid cell activation during immune response, leukocyte activation during immune response, leukocyte mediated immunity,myeloid leukocyte mediated immunity, mast cell mediated immunity, regulation of leukocyte activation, exocytosis,immune response, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction, vesicle-mediated transport, calcium-mediated signaling, second-messenger-mediated signaling, secretion by cell, leukocyte degranulation, mast cell degranulation, regulated secretory pathway, leukocyte activation, mast cell activation,secretion, regulation of T cell activation, regulation of cell activation, regulation of lymphocyte activation,
show all
Cellular Localization:
Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.
show all
Tissue Expression:
Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
show all
Catalog: KA4159C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

Toggle night Mode

{{pinfoXq.title || ''}}

Catalog: {{pinfoXq.catalog || ''}}
Filter:

All

{{item.name}}

{{pinfo.title}}
-{{pinfo.catalog}}

Filter:

{{item.descr}}

Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Learn more
Product {{index}}/{{pcount}}
Prev
Next

{{pvTitle}}

Scroll wheel zooms the picture
{{pvDescr}}