CASP7

Caspase-7 ;
CASP-7 ;
Apoptotic protease Mch-3 ;
CMH-1 ;
ICE-like apoptotic protease 3 ;
ICE-LAP3 ;
[Cleaved into: Caspase-7 subunit p20 ;
Caspase-7 subunit p11]

catalytic activity:Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-.,enzyme regulation:Inhibited by isatin sulfonamides.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.,PTM:Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.,similarity:Belongs to the peptidase C14A family.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.,tissue specificity:Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.,

release of cytochrome c from mitochondria, proteolysis, apoptosis, mitochondrion organization, heart development,cell death, apoptotic mitochondrial changes, response to radiation, response to UV, response to light stimulus,response to abiotic stimulus, programmed cell death, death,

Cytoplasm.

Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.