Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

TNFRSF1A

Tumor necrosis factor receptor superfamily member 1A

TNFRSF1A ;
TNFAR ;
TNFR1 ;
Tumor necrosis factor receptor superfamily member 1A ;
Tumor necrosis factor receptor 1 ;
TNF-R1 ;
Tumor necrosis factor receptor type I ;
TNF-RI ;
TNFR-I ;
p55 ;
p60 ;
CD antigen CD120a

disease:Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS) . FHF is a hereditary periodic fever syndrome characterized by recurrent fever , abdominal pain , localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases. ,domain:Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. ,domain:The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. ,function:Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. ,online information:Repertory of FMF and hereditary autoinflammatory disorders mutations ,PTM:The soluble form is produced from the membrane form by proteolytic processing. ,similarity:Contains 1 death domain. ,similarity:Contains 4 TNFR-Cys repeats. ,subunit:Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS , RIPK1 and possibly FADD , are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades , apoptosis and NF-kappa-B signaling. Interacts with BAG4 , BRE , FEM1B , GRB2 , SQSTM1 and TRPC4AP. Interacts with HCV core protein. ,

response to molecule of bacterial origin , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , protein complex assembly , fatty acid metabolic process , icosanoid metabolic process ,prostanoid metabolic process , prostaglandin metabolic process , apoptosis , defense response , inflammatory response ,immune response , cell death , response to wounding , response to bacterium , defense response , incompatible interaction , defense response to bacterium , incompatible interaction , positive regulation of biosynthetic process ,positive regulation of signal transduction , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade ,positive regulation of gene expression , positive regulation of cell communication , positive regulation of protein kinase cascade , programmed cell death , death , cytokine-mediated signaling pathway , positive regulation of cellular biosynthetic process , positive regulation of defense response , regulation of response to external stimulus , positive regulation of response to external stimulus , response to lipopolysaccharide , unsaturated fatty acid metabolic process ,defense response to bacterium , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade , macromolecular complex subunit organization , innate immune response , regulation of transcription , response to ethanol , regulation of angiogenesis , positive regulation of angiogenesis , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter ,positive regulation of response to stimulus , regulation of inflammatory response , positive regulation of inflammatory response , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process ,regulation of RNA metabolic process , positive regulation of RNA metabolic process , protein oligomerization , protein heterooligomerization , macromolecular complex assembly , protein complex biogenesis ,

Cell membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Secreted . A secreted form is produced through proteolytic processing.; [Isoform 4]: Secreted. Lacks a Golgi-retention motif , is not membrane bound and therefore is secreted.