Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FAS

Tumor necrosis factor receptor superfamily member 6

FAS ;
APT1 ;
FAS1 ;
TNFRSF6 ;
Tumor necrosis factor receptor superfamily member 6 ;
Apo-1 antigen ;
Apoptosis-mediating surface antigen FAS ;
FASLG receptor ;
CD antigen CD95

disease:Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS) . ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. ,domain:Contains a death domain involved in the binding of FADD , and maybe to other cytosolic adapter proteins. ,function:Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance , in the antigen-stimulated suicide of mature T-cells , or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) . ,online information:Mutations in TNFRSF6 causing ALPS type Ia ,similarity:Contains 1 death domain. ,similarity:Contains 3 TNFR-Cys repeats. ,subunit:Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity) . Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. ,tissue specificity:Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. ,

cell activation , leukocyte homeostasis , adaptive immune response , immune effector process , lymphocyte homeostasis ,immunoglobulin production , production of molecular mediator of immune response , leukocyte mediated immunity ,lymphocyte mediated immunity , adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , immune system development , leukocyte differentiation , negative regulation of immune system process , regulation of leukocyte activation , negative regulation of leukocyte activation , renal system process , protein complex assembly , apoptosis , anti-apoptosis , induction of apoptosis , activation-induced cell death of T cells , inflammatory cell apoptosis , transformed cell apoptosis , immune response , cell death , induction of apoptosis by extracellular signals , activation of pro-apoptotic gene products , response to toxin , response to endogenous stimulus , response to hormone stimulus , response to organic substance , regulation of necrotic cell death ,positive regulation of necrotic cell death , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , B cell mediated immunity , hemopoiesis , lymphocyte differentiation , T cell differentiation , response to corticosteroid stimulus , T cell differentiation in the thymus , T cell activation ,homeostatic process , regulation of apoptosis , T cell homeostasis , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , negative T cell selection , macromolecular complex subunit organization , T cell selection ,negative thymic T cell selection , thymic T cell selection , leukocyte activation , regulation of lymphocyte differentiation ,regulation of myeloid cell differentiation , lymphocyte activation , hemopoietic or lymphoid organ development , spleen development , response to steroid hormone stimulus , homeostasis of number of cells , regulation of B cell activation ,regulation of cell activation , negative regulation of cell activation , negative regulation of B cell activation , regulation of lymphocyte activation , negative regulation of lymphocyte activation , protein oligomerization , protein homooligomerization , response to glucocorticoid stimulus , response to protein stimulus , negative regulation of cell death , macromolecular complex assembly , lymphocyte apoptosis , T cell apoptosis , protein complex biogenesis ,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Membrane raft .; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.