disease:A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL6.,similarity:Belongs to the small GTPase superfamily. Rho family.,tissue specificity:Transcribed only in hemopoietic cells.,
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Function:
cell activation, immune system development, leukocyte differentiation, intracellular signaling cascade, small GTPase mediated signal transduction, negative regulation of signal transduction, regulation of protein kinase cascade,negative regulation of cell communication, negative regulation of protein kinase cascade, hemopoiesis, lymphocyte differentiation, T cell differentiation, T cell activation, regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of I-kappaB kinase/NF-kappaB cascade, leukocyte activation, regulation of transcription, lymphocyte activation, hemopoietic or lymphoid organ development,
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Cellular Localization:
Cytoplasm . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Colocalizes together with ZAP70 in the immunological synapse. .