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Total CARP Cell-Based Colorimetric ELISA Kit

-KA3745C

Catalog: KA3745C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
ANKRD1
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Other Name:
Ankyrin repeat domain-containing protein 1 ;
Cardiac ankyrin repeat protein ;
Cytokine-inducible gene C-193 protein ;
Cytokine-inducible nuclear protein ;
show all
Database Link:
Organism Gene ID SwissProt
Human 27063; Q15327;
Mouse Q9CR42;
Rat Q8R560;
Background:
disease:Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.,function:May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.,induction:By TNF, IL1A and parthenolide.,miscellaneous:A chromosomal aberration in the region of ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. Translocation t(10;21)(q23.31;q11.2). The translocation apparently alteres the expression pattern of nearby genes on chromosome 10 by means of a positional effect, and among the genes whose expression pattern is changed due to this chromosomal rearrangement, the ANKRD1 stood out as a plausible candidate gene for TAPVR pathogenesis. This rearrangement apparently does not disrupts any known genes.,similarity:Contains 5 ANK repeats.,subunit:Interacts with YBX1 (By similarity). Interacts with TTN/titin.,tissue specificity:Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.,
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Function:
regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, defense response, regulation of transcription, regulation of RNA metabolic process,
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Cellular Localization:
Nucleus .
show all
Tissue Expression:
Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
show all
Catalog: KA3745C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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