Catalog: KA3743C
Size
Price
Status
Qty.
96well
$330.00
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0
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Main Information
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
IRF4 MUM1
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Protein Name:
Interferon regulatory factor 4
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Other Name:
Interferon regulatory factor 4 ;
IRF-4 ;
Lymphocyte-specific interferon regulatory factor ;
LSIRF ;
Multiple myeloma oncogene 1 ;
NF-EM5 ;
IRF-4 ;
Lymphocyte-specific interferon regulatory factor ;
LSIRF ;
Multiple myeloma oncogene 1 ;
NF-EM5 ;
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Background:
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
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Function:
Disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Lymphoid cells.
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Signaling Pathway
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Catalog: KA3743C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
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