AKAP10

A-kinase anchor protein 10, mitochondrial ;
AKAP-10 ;
Dual specificity A kinase-anchoring protein 2 ;
D-AKAP-2 ;
Protein kinase A-anchoring protein 10 ;
PRKA10 ;

domain:RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.,similarity:Contains 2 RGS domains.,subcellular location:Predominantly mitochondrial but also membrane associated and cytoplasmic.,

protein localization,

Mitochondrion . Membrane . Cytoplasm . Predominantly mitochondrial but also membrane associated and cytoplasmic.