TRIM24

Transcription intermediary factor 1-alpha ;
TIF1-alpha ;
E3 ubiquitin-protein ligase TRIM24 ;
RING finger protein 82 ;
Tripartite motif-containing protein 24 ;

disease:A chromosomal aberration involving TIF1 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(7;10)(q32;q11) with RET. The translocation generates the TIF1/RET (PTC6) oncogene.,function:Interacts selectively in vitro with the AF2-activating domain of the estrogen receptors. Association with DNA-bound estrogen receptors requires the presence of estradiol.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 bromo domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 B box-type zinc fingers.,subunit:Interacts with CBX1 and CBX3 (By similarity). Interacts with NR3C2.,

transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent,transcription from RNA polymerase II promoter, protein complex assembly, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, negative regulation of cell proliferation, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression,negative regulation of gene expression, phosphorylation, negative regulation of transcription, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of response to external stimulus, regulation of response to extracellular stimulus, regulation of response to nutrient levels, RNA biosynthetic process, regulation of cell proliferation, homeostatic process, macromolecular complex subunit organization, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, protein amino acid autophosphorylation, chemical homeostasis, ion homeostasis, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, macromolecular complex assembly, protein complex biogenesis, regulation of vitamin D receptor signaling pathway,

Nucleus . Cytoplasm . Mitochondrion . Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity (PubMed:32324863). .