MAP3K7

Mitogen-activated protein kinase kinase kinase 7 ;
Transforming growth factor-beta-activated kinase 1 ;
TGF-beta-activated kinase 1 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway.,PTM:Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its' repressed activity.,

MAPKKK cascade, angiogenesis, blood vessel development, regulation of cytokine production, positive regulation of cytokine production, embryonic epithelial tube formation, neural tube formation, vasculature development,morphogenesis of an epithelium, activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, positive regulation of immune effector process, regulation of production of molecular mediator of immune response, positive regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, positive regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, positive regulation of lymphocyte mediated immunity,regulation of T cell mediated immunity, positive regulation of T cell mediated immunity, regulation of cytokine production during immune response, positive regulation of cytokine production during immune response, regulation of T cell cytokine production, positive regulation of T cell cytokine production, immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, regulation of adaptive immune response, positive regulation of adaptive immune response,regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, intracellular signaling cascade,protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, activation of NF-kappaB-inducing kinase activity, I-kappaB phosphorylation, embryonic development ending in birth or egg hatching, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, phosphorylation, morphogenesis of embryonic epithelium, regulation of phosphate metabolic process, neural tube development, activation of protein kinase activity, regulation of interleukin-2 production, positive regulation of interleukin-2 production, positive regulation of kinase activity, tube lumen formation, tube morphogenesis, tube development, regulation of phosphorylation, regulation of apoptosis,chordate embryonic development, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade, regulation of MAPKKK cascade, positive regulation of MAPKKK cascade, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, regulation of JNK cascade, positive regulation of JNK cascade,blood vessel morphogenesis, positive regulation of response to stimulus, embryonic morphogenesis, tissue morphogenesis, positive regulation of immune response, antigen receptor-mediated signaling pathway, T cell receptor signaling pathway, regulation of T cell activation, regulation of cell activation, positive regulation of cell activation,positive regulation of T cell activation, regulation of phosphorus metabolic process, positive regulation of multicellular organismal process, regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of transferase activity, positive regulation of transferase activity, epithelium development, negative regulation of cell death, epithelial tube morphogenesis, regulation of stress-activated protein kinase signaling pathway, positive regulation of stress-activated protein kinase signaling pathway, regulation of cellular response to stress,

Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.

Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.