Catalog: YP1554
Size
Price
Status
Qty.
200μL
$600.00
4 weeks
0
100μL
$340.00
4 weeks
0
50μL
$190.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
YAP Phospho Ser397
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
67kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
67kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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YT4924
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YAP (Phospho Ser127) Rabbit pAb
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Total YAP Cell-Based Colorimetric ELISA Kit
KA3612C
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ELISA Kits
YAP (Phospho Ser127) Cell-Based Colorimetric ELISA Kit
KA1392C
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human YAP (Ser397)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
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Gene Name:
YAP1 YAP65
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Protein Name:
Transcriptional coactivator YAP1
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Other Name:
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65 ;
65 kDa Yes-associated protein ;
YAP65 ;
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Database Link:
Background:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development , growth , repair , and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Aug 2013] ,
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Function:
PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Contains 1 WW domain. ,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds , in vitro , through the WW1 domain , to neural isoforms of ENAH that contain the PPSY motif. ,
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Cellular Localization:
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288 , PubMed:20048001) . Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288 , PubMed:20048001) . At low density , predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288 , PubMed:20048001 , PubMed:25849865) . PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271) . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) . .
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Tissue Expression:
Research Areas:
>>Hippo signaling pathway ;
>>Hippo signaling pathway - multiple species
>>Hippo signaling pathway - multiple species
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1554
Size
Price
Status
Qty.
200μL
$600.00
4 weeks
0
100μL
$340.00
4 weeks
0
50μL
$190.00
4 weeks
0
Add to cart
Collected
Collect
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