Synthetic Peptide of Histone H2B (Di Methyl Lys43)

The antibody detects endogenous Histone H2B (Di Methyl Lys43) protein.

HIST1H2BC

Histone H2B type 1-A/Histone H2B type 1-B/Histone H2B type 1-C/E/F/G/I

H2BK43ME2 ;
HIST1H2BA ;
TSH2B ;
Histone H2B type 1-A ;
Histone H2B, testis ;
Testis-specific histone H2B ;
HIST1H2BB ;
H2BFF ;
Histone H2B type 1-B ;
Histone H2B.1 ;
Histone H2B.f ;
H2B/f ;
HIST1H2BC ;
H2BFL ;
HIST1H2BE ;
H2BFH ;
HIST1H2BF ;
H2BFG ;
HIST1H2BG ;
H2BFA ;
HIST1H2BI ;
H2BFK ;
Histone H2B type 1-C/E/F/G/I ;
Histone H2B.1 A ;
Histone H2B.a ;
H2B/a ;
Histone H2B.g ;
H2B/g ;
Histone H2B.h ;
H2B/h ;
Histone H2B.k ;
H2B/k ;
Histone H2B.l ;
H2B/l

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015],

Function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Monoubiquitination of Lys-122 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II.,similarity:Belongs to the histone H2B family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.,tissue specificity:Transcribed exclusively in testis, and the corresponding protein is also present in mature sperm.,

Nucleus . Chromosome .

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