Catalog: YP1425
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
Dok 2 Phospho Tyr351
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
48kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human p56Dok-2 (phospho-Tyr351)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
48kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human p56Dok-2 (Tyr351)
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Specificity:
This antibody detects endogenous levels of Human p56Dok-2 (phospho-Tyr351)
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Gene Name:
DOK2
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Protein Name:
p56Dok-2 (Tyr351)
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Other Name:
Docking protein 2 ;
Downstream of tyrosine kinase 2 ;
p56 ;
dok-2 ;
Downstream of tyrosine kinase 2 ;
p56 ;
dok-2 ;
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Background:
docking protein 2 (DOK2) Homo sapiens The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl) , a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq , Jul 2008] ,
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Function:
Domain:PTB domain mediates receptor interaction. ,Function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4 , as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. ,PTM:On immunoreceptor stimulation , phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. ,similarity:Belongs to the DOK family. Type A subfamily. ,similarity:Contains 1 IRS-type PTB domain. ,similarity:Contains 1 PH domain. ,subunit:Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. ,tissue specificity:Highly expressed in peripheral blood leukocytes , lymph nodes and spleen. Lower expression in thymus , bone marrow and fetal liver. ,
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Cellular Localization:
cytosol ,
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Reference Citation({{totalcount}})
Catalog: YP1425
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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