disease:Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665].,domain:The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.,function:Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.,similarity:Contains 1 agouti domain.,tissue specificity:Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.,
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Function:
cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, neuropeptide signaling pathway, intracellular signaling cascade, behavior, feeding behavior, adult feeding behavior, response to endogenous stimulus, response to hormone stimulus, hormone-mediated signaling, response to organic substance,adult behavior, cellular response to hormone stimulus, eating behavior,
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Cellular Localization:
Secreted . Golgi apparatus lumen .
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Tissue Expression:
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.