Synthesized phosho peptide around human CDCP1 (Tyr743)

This antibody detects endogenous levels of Human CDCP1 (phospho-Tyr743)

CDCP1 TRASK UNQ2486/PRO5773

CDCP1 (Tyr743)

CUB domain-containing protein 1 ;
Membrane glycoprotein gp140 ;
Subtractive immunization M plus HEp3-associated 135 kDa protein ;
SIMA135 ;
Transmembrane and associated with src kinases ;
CD antigen CD318 ;

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq , May 2013] ,

Function:May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. ,PTM:A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding) . Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin , a trypsin-like protease. ,PTM:N-glycosylated. ,PTM:Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin , a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. ,similarity:Contains 1 CUB domain. ,subcellular location:Shedding may also lead to a soluble peptide. ,subunit:Interacts with CDH2/N-cadherin , CDH3/P-cadherin , SDC1/syndecan-1 , SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma. ,tissue specificity:Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney , small intestine , placenta and lung. Up-regulated in a number of human tumor cell lines , as well as in colorectal cancer , breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. ,

[Isoform 1]: Cell membrane ; Single-pass membrane protein . Shedding may also lead to a soluble peptide.; [Isoform 3]: Secreted.