function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP.,
show all
Function:
defense response, immune response, cell surface receptor linked signal transduction, response to organic substance,cytokine-mediated signaling pathway, response to cytokine stimulus, innate immune response, interleukin-1-mediated signaling pathway, response to interleukin-1,
show all
Cellular Localization:
Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .
show all
Tissue Expression:
Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.