function:Cytokine that induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.,induction:Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.,subunit:Interacts with a receptor composed of CRLF2 and IL7R.,tissue specificity:Expressed in a number of tissues including heart, liver and prostate.,
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Cellular Localization:
Secreted .
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Tissue Expression:
Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.