C-X-C motif chemokine ligand 10(CXCL10) Homo sapiens This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014],
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Function:
Function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.,induction:By interferon gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the interferon gamma response.,mass spectrometry: PubMed:11559369,online information:CXCL10 entry,PTM:CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,
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Cellular Localization:
Secreted .
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Tissue Expression:
Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757).