Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CSF2

Granulocyte-macrophage colony-stimulating factor

CSF2 ;
GMCSF ;
Granulocyte-macrophage colony-stimulating factor ;
GM-CSF ;
Colony-stimulating factor ;
CSF ;
Molgramostin ;
Sargramostim

function:Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.,online information:Clinical information on Leukine,pharmaceutical:Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia.,polymorphism:Variant Ile-117 may be a risk factor for atopic asthma.,similarity:Belongs to the GM-CSF family.,subunit:Monomer.,

myeloid dendritic cell activation, cell activation, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, myeloid leukocyte activation, immune system development, leukocyte differentiation, myeloid leukocyte differentiation, regulation of DNA replication, anti-apoptosis, immune response,positive regulation of cell proliferation, positive regulation of biosynthetic process, positive regulation of signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of gene expression, positive regulation of cell communication, positive regulation of protein kinase cascade,regulation of foam cell differentiation, positive regulation of foam cell differentiation, regulation of cell death, regulation of phosphate metabolic process, hemopoiesis, myeloid cell differentiation, positive regulation of cellular biosynthetic process, regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, fluid transport, epithelial fluid transport, regulation of cell proliferation, regulation of cytolysis, regulation of phosphorylation, positive regulation of phosphorylation, regulation of tyrosine phosphorylation of STAT protein, regulation of tyrosine phosphorylation of Stat5 protein, positive regulation of tyrosine phosphorylation of Stat5 protein, positive regulation of tyrosine phosphorylation of STAT protein, regulation of apoptosis, myeloid dendritic cell differentiation, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, leukocyte activation,positive regulation of cell differentiation, positive regulation of DNA replication, regulation of survival gene product expression, positive regulation of survival gene product expression, negative regulation of cytolysis, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of phosphate metabolic process, regulation of JAK-STAT cascade, positive regulation of JAK-STAT cascade, hemopoietic or lymphoid organ development, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of developmental process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of protein metabolic process, negative regulation of cell death,

Secreted .