Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FST

Follistatin

FST ;
Follistatin ;
FS ;
Activin-binding protein

function:Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).,similarity:Contains 1 TB (TGF-beta binding) domain.,similarity:Contains 3 follistatin-like domains.,similarity:Contains 3 Kazal-like domains.,subunit:Monomer .,tissue specificity:Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.,

negative regulation of transcription from RNA polymerase II promoter, hair follicle development, reproductive developmental process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein serine/threonine kinase signaling pathway, gamete generation, pattern specification process, ectoderm development, sex differentiation, cell proliferation, gonad development, epidermis development,female gonad development, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription, sexual reproduction, molting cycle process, hair cycle process, BMP signaling pathway, hair follicle morphogenesis, negative regulation of cellular biosynthetic process, regulation of gonadotropin secretion, negative regulation of gonadotropin secretion, multicellular organism reproduction, molting cycle, odontogenesis of dentine-containing tooth, odontogenesis, hair cycle, regulation of hair cycle, keratinocyte proliferation, regulation of system process, development of primary sexual characteristics, regulation of transcription,negative regulation of cell differentiation, regulation of epidermis development, positive regulation of epidermis development, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, development of primary female sexual characteristics, female sex differentiation, regulation of follicle-stimulating hormone secretion, negative regulation of follicle-stimulating hormone secretion, regulation of hormone secretion, negative regulation of hormone secretion, reproductive structure development, reproductive process in a multicellular organism, tissue morphogenesis, epidermis morphogenesis,regulation of secretion, negative regulation of secretion, negative regulation of transport, positive regulation of developmental process, negative regulation of nitrogen compound metabolic process, positive regulation of multicellular organismal process, regulation of RNA metabolic process, negative regulation of RNA metabolic process,regulation of hair follicle development, positive regulation of hair follicle development, regulation of cellular localization,

Secreted.

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115).