Synthesized peptide derived from human CSFR (Phospho Tyr921)

This antibody detects endogenous levels of CSFR (Phospho Tyr921) Rabbit pAb at Human, Mouse,Rat

CSF1R FMS

Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (Proto-oncogene c-Fms) (CD antigen CD115)

Macrophage colony-stimulating factor 1 receptor ;
CSF-1 receptor ;
CSF-1-R ;
CSF-1R ;
M-CSF-R ;
Proto-oncogene c-Fms ;
CD antigen CD115 ;

colony stimulating factor 1 receptor(CSF1R) Homo sapiens The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPPL1/SHIP2 and THOC5.,tissue specificity:Expressed in bone marrow and in differentiated blood mononuclear cells.,

Cell membrane; Single-pass type I membrane protein.

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>PI3K-Akt signaling pathway ;
>>Osteoclast differentiation ;
>>Hematopoietic cell lineage ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia