Catalog: YP1710
Size
Price
Status
Qty.
200μL
$600.00
4 weeks
0
100μL
$340.00
4 weeks
0
50μL
$190.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
MLKL Phospho Ser345
Host Species
Rabbit
Reactivity
Human
Applications
WB
MW
52kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QNsIS
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
52kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human MLKL Phospho-ser345
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Specificity:
This antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QNsIS
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Gene Name:
MLKL
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Protein Name:
MLKL Phospho-ser345
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Other Name:
Mixed lineage kinase domain-like protein
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Background:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
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Function:
Domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
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Cellular Localization:
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
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Tissue Expression:
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Research Areas:
>>Necroptosis ;
>>TNF signaling pathway ;
>>Salmonella infection
>>TNF signaling pathway ;
>>Salmonella infection
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1710
Size
Price
Status
Qty.
200μL
$600.00
4 weeks
0
100μL
$340.00
4 weeks
0
50μL
$190.00
4 weeks
0
Add to cart
Collected
Collect
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