Catalog: YP1613
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
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Main Information
Target
ROS1 Phospho Tyr2114
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
258kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat ROS (Phospho Tyr2114).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):NDyYR
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
258kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human ROS (Phospho Tyr2114)
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Specificity:
This antibody detects endogenous levels of Human,Mouse,Rat ROS (Phospho Tyr2114).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):NDyYR
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Gene Name:
ROS1 MCF3 ROS
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Protein Name:
ROS1 (Phospho Tyr2114)
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Other Name:
Proto-oncogene tyrosine-protein kinase ROS ;
Proto-oncogene c-Ros ;
Proto-oncogene c-Ros-1 ;
Receptor tyrosine kinase c-ros oncogene 1 ;
c-Ros receptor tyrosine kinase ;
Proto-oncogene c-Ros ;
Proto-oncogene c-Ros-1 ;
Receptor tyrosine kinase c-ros oncogene 1 ;
c-Ros receptor tyrosine kinase ;
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Database Link:
Background:
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.,Function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 fibronectin type-III domains.,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YP1613
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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