Catalog: YP1583
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
Topo IIα Phospho Ser1213
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
174kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human TOP2A (Phospho Ser1213).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LPsPR
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
174kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human TOP2A (Phospho Ser1213)
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Specificity:
This antibody detects endogenous levels of Human TOP2A (Phospho Ser1213).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LPsPR
show all
Gene Name:
TOP2A TOP2
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Protein Name:
DNA topoisomerase 2-alpha (Phospho Ser1213)
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Other Name:
TOP2A ;
TOP2 ;
DNA topoisomerase 2-alpha ;
DNA topoisomerase II ;
alpha isozyme
TOP2 ;
DNA topoisomerase 2-alpha ;
DNA topoisomerase II ;
alpha isozyme
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Database Link:
Background:
catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA.,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.,function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.,PTM:Phosphorylation has no effect on catalytic activity.,similarity:Belongs to the type II topoisomerase family.,subcellular location:Generally located in the nucleoplasm.,subunit:Homodimer. Interacts with COPS5.,
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Function:
DNA metabolic process, DNA replication, DNA topological change, DNA ligation, DNA repair, DNA packaging, apoptosis,response to DNA damage stimulus, nucleus organization, chromosome segregation, intracellular signaling cascade, cell death, regulation of cell death, positive regulation of cell death, programmed cell death, death, second-messenger-mediated signaling, chromosome condensation, apoptotic nuclear changes, apoptotic chromosome condensation,cellular response to stress, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of viral genome replication, positive regulation of viral genome replication, regulation of retroviral genome replication, positive regulation of retroviral genome replication,phosphoinositide-mediated signaling, positive regulation of viral reproduction, regulation of viral reproduction,chromosome organization,
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Cellular Localization:
Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus .
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Tissue Expression:
Research Areas:
>>Platinum drug resistance
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Reference Citation({{totalcount}})
Catalog: YP1583
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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