Catalog: YP1398
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
MCM3 Phospho Ser112
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA, IHC
MW
89kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human MCM3 (phospho-Ser112)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
89kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human MCM3 (Ser112)
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Specificity:
This antibody detects endogenous levels of Human MCM3 (phospho-Ser112)
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Gene Name:
MCM3
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Protein Name:
MCM3 (Ser112)
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Other Name:
MCM3 ;
DNA replication licensing factor MCM3 ;
DNA polymerase alpha holoenzyme-associated protein P1 ;
P1-MCM3 ;
RLF subunit beta ;
p102
DNA replication licensing factor MCM3 ;
DNA polymerase alpha holoenzyme-associated protein P1 ;
P1-MCM3 ;
RLF subunit beta ;
p102
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Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012],
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Function:
Function:Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation.,miscellaneous:Associated with the replication-specific DNA polymerase alpha.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,
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Cellular Localization:
Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
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Tissue Expression:
Research Areas:
>>DNA replication ;
>>Cell cycle
>>Cell cycle
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Signaling Pathway
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Catalog: YP1398
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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