Catalog: YP1393
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
MARCKS Phospho Ser167/170
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
32kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser167 or Ser170,and dually phosphorylated at two sites.
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
32kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human MARCKS (Ser167 and 170)
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Specificity:
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser167 or Ser170,and dually phosphorylated at two sites.
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Gene Name:
MARCKS MACS PRKCSL
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Protein Name:
MARCKS (Ser167/170)
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Other Name:
Myristoylated alanine-rich C-kinase substrate ;
MARCKS ;
Protein kinase C substrate, 80 kDa protein, light chain ;
80K-L protein ;
PKCSL ;
MARCKS ;
Protein kinase C substrate, 80 kDa protein, light chain ;
80K-L protein ;
PKCSL ;
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Background:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008],
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Function:
Function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family.,
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Cellular Localization:
Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor .
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Tissue Expression:
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Research Areas:
>>Fc gamma R-mediated phagocytosis ;
>>MicroRNAs in cancer
>>MicroRNAs in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1393
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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