Catalog: YP1347
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
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Main Information
Target
GIT2 Phospho Tyr392
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
84kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human GIT2 (phospho-Tyr392)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
84kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human GIT2 (Tyr392)
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Specificity:
This antibody detects endogenous levels of Human GIT2 (phospho-Tyr392)
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Gene Name:
GIT2 KIAA0148
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Protein Name:
GIT2 (Tyr392)
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Other Name:
ARF GTPase-activating protein GIT2 ;
ARF GAP GIT2 ;
Cool-interacting tyrosine-phosphorylated protein 2 ;
CAT-2 ;
CAT2 ;
G protein-coupled receptor kinase-interactor 2 ;
GRK-interacting protein 2 ;
ARF GAP GIT2 ;
Cool-interacting tyrosine-phosphorylated protein 2 ;
CAT-2 ;
CAT2 ;
G protein-coupled receptor kinase-interactor 2 ;
GRK-interacting protein 2 ;
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Background:
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G
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Function:
Alternative products:Additional isoforms seem to exist,Function:GTPase-activating protein for the ADP ribosylation factor family.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors.,
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Cellular Localization:
nucleoplasm,focal adhesion,
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Tissue Expression:
Research Areas:
>>Endocytosis ;
>>Yersinia infection
>>Yersinia infection
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Reference Citation({{totalcount}})
Catalog: YP1347
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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