Catalog: YP1231
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
GRK 2 Phospho Tyr86
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, WB
MW
75kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:50-200; WB 1:500-2000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous phospho levels of GRK2 (Phospho-Tyr86) at Human:Y86, Mouse:Y86, Rat:Y86.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EFyEE
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
75kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human GRK2 (Phospho-Tyr86)
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Specificity:
This antibody detects endogenous phospho levels of GRK2 (Phospho-Tyr86) at Human:Y86, Mouse:Y86, Rat:Y86.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EFyEE
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Gene Name:
ADRBK1 BARK BARK1 GRK2
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Protein Name:
GRK2 (Phospho-Tyr86)
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Other Name:
ADRBK1 ;
BARK ;
BARK1 ;
GRK2 ;
Beta-adrenergic receptor kinase 1 ;
Beta-ARK-1 ;
G-protein coupled receptor kinase 2
BARK ;
BARK1 ;
GRK2 ;
Beta-adrenergic receptor kinase 1 ;
Beta-ARK-1 ;
G-protein coupled receptor kinase 2
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Background:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes.,
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Cellular Localization:
Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .
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Tissue Expression:
Research Areas:
>>Chemokine signaling pathway ;
>>Endocytosis ;
>>Hedgehog signaling pathway ;
>>Glutamatergic synapse ;
>>Olfactory transduction ;
>>Morphine addiction
>>Endocytosis ;
>>Hedgehog signaling pathway ;
>>Glutamatergic synapse ;
>>Olfactory transduction ;
>>Morphine addiction
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1231
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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