Catalog: YP1078
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
APLF Phospho Ser116
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
57kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-APLF (S116) Polyclonal Antibody detects endogenous levels of APLF protein only when phosphorylated at S116.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RNsQV
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
57kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human APLF around the phosphorylation site of Ser116. AA range:82-131
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Specificity:
Phospho-APLF (S116) Polyclonal Antibody detects endogenous levels of APLF protein only when phosphorylated at S116.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RNsQV
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Gene Name:
APLF
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Protein Name:
Aprataxin and PNK-like factor
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Other Name:
APLF ;
C2orf13 ;
PALF ;
XIP1 ;
Aprataxin and PNK-like factor ;
Apurinic-apyrimidinic endonuclease APLF ;
PNK and APTX-like FHA domain-containing protein ;
XRCC1-interacting protein 1
C2orf13 ;
PALF ;
XIP1 ;
Aprataxin and PNK-like factor ;
Apurinic-apyrimidinic endonuclease APLF ;
PNK and APTX-like FHA domain-containing protein ;
XRCC1-interacting protein 1
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Background:
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008],
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Function:
Domain:The FHA-like domain mediates interaction with XRCC1 and XRCC4.,Function:Involved in single-strand and double-strand DNA break repair.,PTM:Phosphorylated in an ATM-dependent manner upon double-strand DNA break.,similarity:Contains 1 FHA-like domain.,similarity:Contains 2 C2H2-type zinc fingers.,subcellular location:Colocalizes with XRCC1 at sites of DNA damage.,subunit:Interacts with XRCC1. May also interact with XRCC4 and XRCC5.,
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Cellular Localization:
Nucleus . Chromosome . Cytoplasm, cytosol . Localizes to DNA damage sites (PubMed:18474613, PubMed:18172500, PubMed:21211721, PubMed:23689425). Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (PubMed:18172500). .
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Tissue Expression:
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Reference Citation({{totalcount}})
Catalog: YP1078
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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