Catalog: YP1068
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
APC1 Phospho Ser355
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
217kD (Calculated)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-APC1 (S355) Polyclonal Antibody detects endogenous levels of APC1 protein only when phosphorylated at S355.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AHsPA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
217kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human APC1 around the phosphorylation site of Ser355. AA range:321-370
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Specificity:
Phospho-APC1 (S355) Polyclonal Antibody detects endogenous levels of APC1 protein only when phosphorylated at S355.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):AHsPA
show all
Gene Name:
ANAPC1
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Protein Name:
Anaphase-promoting complex subunit 1
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Other Name:
ANAPC1 ;
TSG24 ;
Anaphase-promoting complex subunit 1 ;
APC1 ;
Cyclosome subunit 1 ;
Mitotic checkpoint regulator ;
Testis-specific gene 24 protein
TSG24 ;
Anaphase-promoting complex subunit 1 ;
APC1 ;
Cyclosome subunit 1 ;
Mitotic checkpoint regulator ;
Testis-specific gene 24 protein
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Background:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011],
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Function:
Function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.,similarity:Belongs to the APC1 family.,similarity:Contains 4 PC repeats.,subunit:The APC/C is composed of at least 11 subunits.,
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Cellular Localization:
nucleoplasm,anaphase-promoting complex,cytosol,
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Tissue Expression:
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Research Areas:
>>Cell cycle ;
>>Oocyte meiosis ;
>>Ubiquitin mediated proteolysis ;
>>Progesterone-mediated oocyte maturation ;
>>Human T-cell leukemia virus 1 infection
>>Oocyte meiosis ;
>>Ubiquitin mediated proteolysis ;
>>Progesterone-mediated oocyte maturation ;
>>Human T-cell leukemia virus 1 infection
show all
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1068
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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