Catalog: YP0415
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
SH-PTP1 Phospho Tyr564
Host Species
Rabbit
Reactivity
Human, Monkey
Applications
WB, IHC, ELISA
MW
70kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-SH-PTP1 (Y564) Polyclonal Antibody detects endogenous levels of SH-PTP1 protein only when phosphorylated at Y564.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DVyEN
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
70kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Primary Antibodies
SH-PTP1 (Phospho Tyr564) Rabbit pAb
YP0415
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ELISA Kits
Total SHP-1 Cell-Based Colorimetric ELISA Kit
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SHP-1 (Phospho Tyr564) Cell-Based Colorimetric ELISA Kit
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human SHP-1 around the phosphorylation site of Tyr564. AA range:530-579
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Specificity:
Phospho-SH-PTP1 (Y564) Polyclonal Antibody detects endogenous levels of SH-PTP1 protein only when phosphorylated at Y564.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DVyEN
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Gene Name:
PTPN6
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Protein Name:
Tyrosine-protein phosphatase non-receptor type 6
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Other Name:
PTPN6 ;
HCP ;
PTP1C ;
Tyrosine-protein phosphatase non-receptor type 6 ;
Hematopoietic cell protein-tyrosine phosphatase ;
Protein-tyrosine phosphatase 1C ;
PTP-1C ;
Protein-tyrosine phosphatase SHP-1 ;
SH-PTP1
HCP ;
PTP1C ;
Tyrosine-protein phosphatase non-receptor type 6 ;
Hematopoietic cell protein-tyrosine phosphatase ;
Protein-tyrosine phosphatase 1C ;
PTP-1C ;
Protein-tyrosine phosphatase SHP-1 ;
SH-PTP1
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Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth , differentiation , mitotic cycle , and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains , which act as protein phospho-tyrosine binding domains , and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells , and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with , and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene , which encode distinct isoforms , have been reported. [provided by RefSeq , Jul
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Function:
Catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,Function:Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1 , induces UBE2V2 expression upon angiotensin II stimulation. ,PTM:Phosphorylated on serine and tyrosine residues. ,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. ,similarity:Contains 1 tyrosine-protein phosphatase domain. ,similarity:Contains 2 SH2 domains. ,subcellular location:In neurons , translocates into the nucleus after treatment with angiotensin II. ,subunit:Monomer. Interacts with MTUS1 (By similarity) . Binds PTPNS1 , LILRB1 and LILRB2. Interacts with FCRL2 , FCRL3 , FCRL4 , CD300LF and CD84. ,tissue specificity:Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells. ,
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Cellular Localization:
Cytoplasm. Nucleus. In neurons , translocates into the nucleus after treatment with angiotensin II (By similarity) . Shuttles between the cytoplasm and nucleus via its association with PDPK1. .
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Tissue Expression:
Research Areas:
>>Adherens junction ;
>>JAK-STAT signaling pathway ;
>>Natural killer cell mediated cytotoxicity ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway ;
>>Pathogenic Escherichia coli infection ;
>>Leishmaniasis ;
>>Proteoglycans in cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer
>>JAK-STAT signaling pathway ;
>>Natural killer cell mediated cytotoxicity ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway ;
>>Pathogenic Escherichia coli infection ;
>>Leishmaniasis ;
>>Proteoglycans in cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer
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Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Adherens junction
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> B cell receptor signaling pathway
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
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Catalog: YP0415
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
50μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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