The antiserum was produced against synthesized peptide derived from human c-Jun around the phosphorylation site of Ser73. AA range:40-89

This antibody detects endogenous c-Jun only when phosphorylated at Ser73 and endogenous d-Jun only when phosphorylated at ser100.

JUN/JUND

Transcription factor AP-1;jun;c-jun；AP-1; Transcription factor jun-D

JUN ;
Transcription factor AP-1 ;
Activator protein 1 ;
AP1 ;
Proto-oncogene c-Jun ;
V-jun avian sarcoma virus 17 oncogene homolog ;
p39 ;
JUND ;
Transcription factor jun-D

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein , and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31 , a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq , Jul 2008] ,

Function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. ,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC. ,similarity:Belongs to the bZIP family. ,similarity:Belongs to the bZIP family. Jun subfamily. ,similarity:Contains 1 bZIP domain. ,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity) . Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A , SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. ,

Nucleus.

>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>cAMP signaling pathway ;
>>Mitophagy - animal ;
>>Apoptosis ;
>>Wnt signaling pathway ;
>>Osteoclast differentiation ;
>>Focal adhesion ;
>>Tight junction ;
>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway ;
>>TNF signaling pathway ;
>>Neurotrophin signaling pathway ;
>>GnRH signaling pathway ;
>>Estrogen signaling pathway ;
>>Oxytocin signaling pathway ;
>>Relaxin signaling pathway ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Pertussis ;
>>Yersinia infection ;
>>Leishmaniasis ;
>>Chagas disease ;
>>Hepatitis B ;
>>Measles ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Chemical carcinogenesis - receptor activation ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Colorectal cancer ;
>>Renal cell carcinoma ;
>>Breast cancer ;
>>Choline metabolism in cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Inflammatory bowel disease ;
>>Rheumatoid arthritis ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis