Catalog: YP0476
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
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Main Information
Target
RPA2 Phospho Ser33
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
32kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-RPA p32 (S33) Polyclonal Antibody detects endogenous levels of RPA p32 protein only when phosphorylated at S33.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):APsQA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
32kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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RPA32/RPA2 Rabbit pAb
YT4170
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RPA32/RPA2 (Phospho Thr21) Rabbit pAb
YP0743
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Primary Antibodies
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RPA32/RPA2 (Phospho Ser33) Rabbit pAb
YP0476
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ELISA Kits
Total RFA2 Cell-Based Colorimetric ELISA Kit
KA4267C
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ELISA Kits
RFA2 (Phospho Ser33) Cell-Based Colorimetric ELISA Kit
KA1758C
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ELISA Kits
RFA2 (Phospho Thr21) Cell-Based Colorimetric ELISA Kit
KA1472C
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human RFA2 around the phosphorylation site of Ser33. AA range:1-50
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Specificity:
Phospho-RPA p32 (S33) Polyclonal Antibody detects endogenous levels of RPA p32 protein only when phosphorylated at S33.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):APsQA
show all
Gene Name:
RPA2
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Protein Name:
Replication protein A 32 kDa subunit
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Other Name:
RPA2 ;
REPA2 ;
RPA32 ;
RPA34 ;
Replication protein A 32 kDa subunit ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34
REPA2 ;
RPA32 ;
RPA34 ;
Replication protein A 32 kDa subunit ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34
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Background:
function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,
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Function:
Function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,
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Cellular Localization:
Nucleus . Nucleus, PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .
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Tissue Expression:
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Research Areas:
>>DNA replication ;
>>Nucleotide excision repair ;
>>Mismatch repair ;
>>Homologous recombination ;
>>Fanconi anemia pathway
>>Nucleotide excision repair ;
>>Mismatch repair ;
>>Homologous recombination ;
>>Fanconi anemia pathway
show all
Reference Citation({{totalcount}})
Catalog: YP0476
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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