Catalog: YP1244
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
MLKL Phospho Ser358
Host Species
Rabbit
Reactivity
Human
Applications
IHC, IF
MW
55kD (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
IHC 1:100-500; IF/ICC1:100-500
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous phospho levels of MLKL (phospho S358)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
55kD
Modification
phosphate
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human MLKL (phospho S358)
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Specificity:
This antibody detects endogenous phospho levels of MLKL (phospho S358)
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Gene Name:
MLKL
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Protein Name:
MLKL (phospho S358)
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Other Name:
Mixed lineage kinase domain-like protein
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Background:
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
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Function:
Domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
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Cellular Localization:
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
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Tissue Expression:
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Research Areas:
>>Necroptosis ;
>>TNF signaling pathway ;
>>Salmonella infection
>>TNF signaling pathway ;
>>Salmonella infection
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1244
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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