Catalog: YP0377
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Main Information
Target
C3G Phospho Tyr504
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, ELISA
MW
120kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Phospho-C3G (Y504) Polyclonal Antibody detects endogenous levels of C3G protein only when phosphorylated at Y504.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VPyAP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
120kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human RapGEF1 around the phosphorylation site of Tyr504. AA range:470-519
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Specificity:
Phospho-C3G (Y504) Polyclonal Antibody detects endogenous levels of C3G protein only when phosphorylated at Y504.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VPyAP
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Gene Name:
RAPGEF1
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Protein Name:
Rap guanine nucleotide exchange factor 1
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Other Name:
RAPGEF1 ;
GRF2 ;
Rap guanine nucleotide exchange factor 1 ;
CRK SH3-binding GNRP ;
Guanine nucleotide-releasing factor 2 ;
Protein C3G
GRF2 ;
Rap guanine nucleotide exchange factor 1 ;
CRK SH3-binding GNRP ;
Guanine nucleotide-releasing factor 2 ;
Protein C3G
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Background:
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008],
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Function:
Function:Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,subunit:Interacts with CRK via its SH3-binding sites.,tissue specificity:Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.,
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Cellular Localization:
Early endosome .
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Tissue Expression:
Research Areas:
>>Rap1 signaling pathway ;
>>Focal adhesion ;
>>Neurotrophin signaling pathway ;
>>Insulin signaling pathway ;
>>Renal cell carcinoma
>>Focal adhesion ;
>>Neurotrophin signaling pathway ;
>>Insulin signaling pathway ;
>>Renal cell carcinoma
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Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Human Diseases >> Cancer: specific types >> Renal cell carcinoma
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
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Catalog: YP0377
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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